Ed Reed recorded the most regular-season interceptions in the NFL from 2000 through 2025 with 64. Charles Woodson ranks second with 59 during the same period, while Darren Sharper is third with 58.
Reed owns a five-interception lead over Woodson, but the date range changes several familiar career totals. Woodson, Sharper, Champ Bailey, Ronde Barber and Dré Bly all recorded interceptions before 2000 that do not count here.
For the complete record across every era, see the NFL’s all-time interception leaders.
Table of Contents
Method and Scope
This leaderboard counts defensive interceptions recorded during the 2000 through 2025 NFL regular seasons. Postseason interceptions are excluded.
Players who entered the league before 2000 receive credit only for interceptions made inside the stated window. Woodson finished his career with 65 interceptions, but six came in 1998 and 1999. His total here is therefore 59.
Tied players share a rank, and the following rank is skipped. The table contains 50 players, but four players share 47th place with 27 interceptions, so its final displayed rank is T-47.
Most Interceptions Since 2000: Top 10 Analysis
10. Harrison Smith: 39 Interceptions
Harrison Smith reached 39 interceptions after adding two in 2025. His career is the only one in this top 10 that extended through the final season covered by the leaderboard.
Smith also recorded 21.5 sacks, giving him an unusually broad statistical profile for a safety with this much ball production.
9. Dré Bly: 40 Interceptions
Dré Bly recorded 40 interceptions from 2000 onward. His complete career total was 43, but three came during his 1999 rookie season.
Bly collected six interceptions in 2001, 2003 and 2005. Those three peaks account for nearly half of his total within this period.
8. Terence Newman: 42 Interceptions
Terence Newman recorded all 42 of his interceptions after entering the NFL in 2003. He made four as a rookie and remained in the league for 15 seasons.
Newman’s 221 regular-season games are the most among the top 10 players whose full careers occurred within the statistical window.
T-6. Ronde Barber: 43 Interceptions
Ronde Barber recorded 43 interceptions from 2000 onward. Four more came in 1998 and 1999, giving him 47 across his complete career.
His biggest season inside the window came in 2001, when he intercepted 10 passes. Barber also recorded 24 sacks during the period, reflecting how often he affected games from outside traditional coverage assignments.
T-6. DeAngelo Hall: 43 Interceptions
DeAngelo Hall finished with 43 career interceptions, all of which count because he entered the league in 2004. He shares sixth place with Barber.
Hall recorded six interceptions in both 2005 and 2010. He returned five of his career picks for touchdowns.
5. Champ Bailey: 47 Interceptions
Champ Bailey made 47 interceptions from 2000 onward. His full career total was 52, with five coming during his 1999 rookie season.
Bailey’s peak came in 2006, when he intercepted 10 passes. That season accounts for more than one-fifth of his total on this leaderboard.
4. Asante Samuel: 51 Interceptions
Asante Samuel recorded 51 interceptions from 2003 through 2013. He is one of only four players to reach 50 within the 2000 through 2025 window.
Samuel made a career-high 10 interceptions in 2006 and returned six career picks for touchdowns.
3. Darren Sharper: 58 Interceptions
Darren Sharper recorded 58 interceptions from 2000 through 2010. His complete career total was 63, but five came from 1997 through 1999.
Sharper reached nine interceptions in 2000, 2005 and 2009. His adjusted total leaves him one behind Woodson for second place.
2. Charles Woodson: 59 Interceptions
Charles Woodson made 59 interceptions from 2000 through 2015. His six interceptions from his first two seasons fall outside this leaderboard.
Woodson led the league with nine interceptions in 2009 and seven in 2011. He returned nine of his interceptions during this period for touchdowns.
1. Ed Reed: 64 Interceptions
Ed Reed leads the period with 64 interceptions, all recorded between 2002 and 2013. He reached nine interceptions twice and led the league three times.
Reed also produced 1,590 interception return yards, the most in NFL history. That return value separates him further from a leaderboard already led by five interceptions.
What the Leaderboard Shows
The Top Three Created Separation
Only one interception separates Woodson from Sharper, but there is a seven-pick drop from Sharper in third to Samuel in fourth. Reed, Woodson and Sharper form a clear top group within this era.
The 2000 Cutoff Changes Several Placements
Woodson loses six interceptions to the cutoff, Sharper and Bailey lose five each, Barber loses four and Bly loses three. Without the fixed starting point, Woodson would move ahead of Reed and Sharper would be only one interception behind him.
Interception Totals Cluster Quickly After the Leaders
The difference between Reed in first place and Smith in 10th is 25 interceptions. The next 40 players fit inside a much narrower 11-interception span, from 38 down to 27.
Modern windows create a different group of leaders. Compare this list with the players who have recorded the most NFL interceptions since 2015 and the interception leaders since 2020.
Complete Top 50 NFL Interception Leaders Since 2000
The table uses regular-season interceptions only and applies shared ranks to tied totals.
| Rank | Player | Interceptions |
|---|---|---|
| 1 | Ed Reed | 64 |
| 2 | Charles Woodson | 59 |
| 3 | Darren Sharper | 58 |
| 4 | Asante Samuel | 51 |
| 5 | Champ Bailey | 47 |
| T-6 | DeAngelo Hall | 43 |
| T-6 | Ronde Barber | 43 |
| 8 | Terence Newman | 42 |
| 9 | Dré Bly | 40 |
| 10 | Harrison Smith | 39 |
| T-11 | Reggie Nelson | 38 |
| T-11 | Charles Tillman | 38 |
| 13 | Richard Sherman | 37 |
| T-14 | Kevin Byard III | 36 |
| T-14 | Tyrann Mathieu | 36 |
| T-14 | Patrick Peterson | 36 |
| T-14 | Nate Clements | 36 |
| T-18 | Devin McCourty | 35 |
| T-18 | Aqib Talib | 35 |
| T-20 | Tramon Williams | 34 |
| T-20 | Deltha O’Neal | 34 |
| T-22 | Marcus Peters | 33 |
| T-22 | Tashaun Gipson Sr. | 33 |
| T-22 | Brent Grimes | 33 |
| T-22 | Ty Law | 33 |
| T-22 | Patrick Surtain | 33 |
| T-27 | Justin Simmons | 32 |
| T-27 | Stephon Gilmore | 32 |
| T-27 | Johnathan Joseph | 32 |
| T-27 | Rashean Mathis | 32 |
| T-27 | Troy Polamalu | 32 |
| T-27 | Tory James | 32 |
| T-33 | Antonio Cromartie | 31 |
| T-33 | Anthony Henry | 31 |
| T-35 | Earl Thomas | 30 |
| T-35 | Dominique Rodgers-Cromartie | 30 |
| T-35 | Mike Adams | 30 |
| T-35 | Deon Grant | 30 |
| T-35 | Sammy Knight | 30 |
| T-40 | Xavien Howard | 29 |
| T-40 | Joe Haden | 29 |
| T-40 | Darrelle Revis | 29 |
| T-40 | Eric Weddle | 29 |
| T-40 | Greg Wesley | 29 |
| T-45 | Darius Slay | 28 |
| T-45 | Tony Parrish | 28 |
| T-47 | Jessie Bates III | 27 |
| T-47 | Janoris Jenkins | 27 |
| T-47 | Leon Hall | 27 |
| T-47 | Chris Gamble | 27 |
Frequently Asked Questions
Who has the most interceptions in the NFL since 2000?
Ed Reed leads with 64 regular-season interceptions recorded from 2000 through 2025.
Why does Charles Woodson have 59 interceptions on this list instead of 65?
Woodson recorded six interceptions before 2000. Only his 59 interceptions from the 2000 season onward count here.
Are playoff interceptions included?
No. The leaderboard includes regular-season defensive interceptions only.
Why does the top-50 table end at T-47?
Jessie Bates III, Janoris Jenkins, Leon Hall and Chris Gamble are tied with 27 interceptions. All four share 47th place, creating 50 total rows without separate ranks 48 through 50.
Conclusion
Reed leads the 2000 through 2025 interception leaderboard with 64, five ahead of Woodson. His advantage becomes even more meaningful when paired with his record 1,590 return yards, while the sharp drop after the top three separates Reed, Woodson and Sharper from the rest of the period.
Related Interception Rankings
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